Collagen Peptides

A Clinically Proven Tool for Musculoskeletal Health

Erica Zelfand February 1 2020

Collagen Peptides

A Clinically Proven Tool for Musculoskeletal Health

Erica Zelfand February 1 2020

Collagen Peptides


A Clinically Proven Tool for Musculoskeletal Health

Erica Zelfand


Collagen: the protein that holds us together.

It isn’t merely a metaphor to say collagen holds us together: 75 to 80% of our skin and 30% of our total body protein is made of collagen.1 Collagen is the most abundant protein in the body, important for the integrity and health of our skin, hair, bones, tendons, ligaments, and cartilage.

Found in the articular cartilage that covers the ends of our bones where they come together to form joints,2 collagen enables the joints to withstand forces of compression, thus protecting the bones from injury.3 Our bodies have limited ability, however, to repair and replace cartilage, which is why joint integrity tends to decline with age.4

How does collagen supplementation work?

Because collagen products are sourced from animals, the amino acid composition of the peptides found in collagen supplements is similar to that of the collagen in the cartilage of our joints. Those peptides are well absorbed by the gut after ingestion, making their way into the bloodstream and eventually accumulating in the cartilage and skin.56

Although eating meat—whether it be that of a chicken, cow, fish, or other animal—provides us with many amino acids, it doesn’t support connective tissue health in quite the same manner as does collagen. Collagen is rich in the amino acid glycine,7 containing up to 20 times more glycine than meat. In addition to helping build connective tissue like tendons and muscle,8 glycine has also been shown to support mood, sleep, and metabolism.9

Preliminary evidence suggests that supplementation with collagen activates the body’s own collagen biosynthesis in chondrocytes, the cells in the body that make cartilage.10 Research has demonstrated these effects particularly in conditions in where the cartilage is stressed.11 Additionally, other studies have suggested collagen supplementation may have an immunomodulatory effect1213 and may thus be supportive in autoimmune diseases such as rheumatoid arthritis. With respect to skin health, collagen has further been shown to support the integrity, moisture, elasticity, and suppleness of the skin, and even decrease wrinkles and other signs of aging.1415

To extract collagen for at-home consumption, the bones and/or skin of an animal must be boiled for hours and the broth consumed. This can create a tasty soup base, but is also a time-consuming task that can be hard to do on a daily basis. Fortunately, collagen supplements are a convenient alternative to help us quickly and easily get collagen into our bodies. Furthermore, it has been shown that the hydrolyzed collagen (HC) found in quality supplements is easier to absorb than the collagen found in home-cooked preparations.16 Because of the low molecular weight of peptides found in HC, they are much more easily absorbed and bioavailable—with animal studies suggesting up to 95% absorbability when taken orally.5

As of 2015, there were over 60 scientific studies demonstrating the benefits of HC on a host of conditions associated with the aging process, including osteoarthritis,17 osteoporosis,18 and even skin problems.19 In their review of these studies, the authors conclude “HC continual ingestion helps to reduce and prevent joint pain, bone density loss and skin aging. These results as well as its high level of tolerance and safety make HC ingestion attractive for a long-term use in bone and joint degenerative diseases and in the fight against skin aging.”20

Not just for aging, collagen also benefits athletic performance

The benefits of HC are not just experienced with age-related disease; many studies also show benefits in healthy athletes. In one such study, healthy, competitive male mountain bikers and female basketball players consumed 10 grams of HC enhanced with B vitamins and magnesium daily for six months.21 At the end of the six months, ultrasounds performed on the shoulders and knees of the athletes demonstrated statistically significant increases of cartilage thickness. The control subjects, on the other hand, either had no improvements in cartilage thickness, or a decrease.

In another study, 84 athletes (with an average age of 41 years) consumed 10 grams of HC daily for 12 weeks. Of the participants—all of whom had joint pain in either the knee, hip, and/or shoulder at the beginning of the trial—most reported reduced pain both at rest and during test exercises after supplementing with HC.22 In a recent study, athletes with ankle instability were supplemented with five grams of collagen peptides or placebo daily for six months.23 Athletes taking the collagen peptides had significant improvements in ankle stability (as assessed by multiple standardized scoring tools and athlete perception) compared with those taking the placebo. Additionally, there was a significant decline in ankle injuries in those taking the collagen peptides at the three-month follow-up after the intervention.

Finally, collagen peptide supplementation also has been shown to enhance lean body mass in athletes. In a 2019 study, active young men engaging in a resistance training exercise program were supplemented with 15 grams of collagen peptides or placebo daily for 12 weeks.24 At the end of the training period, the group receiving the collagen peptides had a significant increase in fat-free mass compared to placebo. The placebo group, on the other hand, had a significant increase in body fat mass while no change was seen in those taking the collagen peptides.

Thank goodness for collagen

When the demands of gravity, physical stress, and injury chip away at the body, we can thankfully turn to the basic connective-tissue-building-blocks found in collagen and the naturally derived, easy-to-absorb products in which they’re found. Collagen is, after all, the nutrient that holds us together.


Dr. Erica Zelfand is an integrative family physician, medical writer/editor, and public speaker. She is deeply committed to a patient-centered, root-cause-oriented, nature-honoring approach to healing. To learn more and connect, please visit vvmv.

1. Proksch E, Jensen J. Skin as an organ of protection. In: Goldsmith LA, et al. Fitzpatrick’s Dermatology in General Medicine. 8th ed. New York: McGraw-Hill; 2012.

2. Mow VC, et al. Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. Biomaterials. 1992; 13:67-97.

3. Buckwalter JA, Mankin HJ. Articular cartilage: tissue design and chondrocytes-matrix interactions. Instr Course Lect. 1998;47:477-86.

4. Hou A, et al. Cellular senescence in osteoarthritis and anti-aging strategies. Mech Ageing Dev. 2018 Aug 11.

5. Oesser S, et al. Oral administration of 14C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). JNutr 1999; 129:1891-5.

6. Zague V. A new view concerning the effects of collagen hydrolysate intake on skin properties. Arch Dermatol Res. 2008 Oct;300(9):479 83.

7. Eastoe JE. The amino acid composition of mammalian collagen and gelatin. Biochem J. 1955 Dec;61(4):589600.

8. Tack C, et al. The physiological mechanisms of effect of vitamins and amino acids on tendon and muscle healing: a systematic review. Int J Sport Nutr Exerc Metab. 2018 May 1;28(3):294-311.

9. BannaiM, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quali ty of sleep. J Pharmacol Sci. 2012; 118(2): 145-8.

10. Kasper, H. Nutrition and degenerative joint disease: the chondroprotective effect of gelatine. Med Welt. 2003;3(54): 47-9.

11. Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 2006;22:2221-32.

12. Barnett ML, et al. Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 1998 Feb;41(2):290-7.

13. Wei W, et al. A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Res Ther. 2009; 11(6) :R180.

14. Shimizu J, et al. Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxy prolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochem Biophys Res Commun.

2015 Jan 9;456(2):626-30.

15. Inoue N, et al. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial aging signs in a randomized double-blind placebo-controlled clinical study. J Sci Food Agric.

2016 Sep;96(12):4077-81.

16. AlcockRD, et al. Bone broth unlikely to provide reliable concentrations of collagen precursors compared to supplemental sources of collagen used in collagen research. Int J Sport Nutr Exerc Metab. 2018 Jun 12:1-24.

17. Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 2006 Nov;22(11):2221-32.

18. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000 Oct; 30(2):87-99.

19. Kirn DU, et al. Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: A randomized, double-blind, placebo-controlled study. Nutrients. 2018 Jun 26; 10(7).

20. Figueres Juher T, Bases Perez E. [An overview of the beneficial effects of hydrolyzed collagen intake on joint and bone health and on skin aging, j Nutr Hosp. 2015 Jul 18;32 Suppl 1:62-6.

21. Fernandez JL, Perez OM. Effects of gelatine hydrolysates in the prevention of athletic injuries. Archivos de Medicina del Deporte. 1998; 15:277-82.

22. Flechsenhar KR, Alf D. Results of a postmarketing surveillance study. Orthopaedische Praxis. 2005;41:486 94.

23. Dressier P, et al. Improvement of functional ankle properties following supplementation with specific collagen peptides in athletes with chronic ankle instability. J Sports Sci Med. 2018 May 14; 17(2):298-304.

24. Kirmse M, et al. Prolonged collagen peptide supplementation and resistance exercise training affects body composition in recreationally active men. Nutrients. 2019 May 23; 11(5).